www.makemkv.com

When trying to open either an ISO or the disc, MKV fails to open. ANyone experience this who might have a solution?

"My car doesn't work. Any ideas?"

Without more information, that's what your request is.

What error messages are you getting? The FAQ in my signature is a good place to start for help, with turning on debug logging.

Here's the log file contents:

Debug log started at Sat Sep 16 19:46:02 2017 , written by MakeMKV v1.10.7 win(x64-release)
Using 524544KB for read cache.
001005:0000 MakeMKV v1.10.7 win(x64-release) started
001004:0000 Debug logging enabled, log will be saved as C:\Users\Administrator/MakeMKV_log.txt
003007:0000 Using direct disc access mode
003002:0000 Calculated BUP offset for VTS #0 does not match one in IFO header.
003002:0000 Calculated BUP offset for VTS #3 does not match one in IFO header.
005010:0000 Failed to open disc
Application exited at Sat Sep 16 19:46:38 2017

Those errors are consistent with problems reading the directory of the disk. Have you cleaned it?

I'm actually reading a data file, it's an ISO that I made of my disc so that I could play it from my server, I'm now wanting to convert the main movie into an MKv.

My suggestion is to follow the FAQ link in my signature, and send the information you can to support@makemkv.com for Mike to look at it. For the log portion, try opening the disk directly AND the ISO in the same log, so Mike has more information.